BT3001 Bioprocess Control and Instrumentation Syllabus:

BT3001 Bioprocess Control and Instrumentation Syllabus – Anna University Regulation 2021:

UNIT I BIOCHEMICAL PROCESS VARIABLES AND THEIR MEASUREMENTS

Temperature, flow measurement and control, Pressure measurement and control, shaft power, rate of stirring, detection and prevention of foam, measurement of cells, measurement and control of dissolved oxygen, inlet and outlet gas analysis, pH measurement and control

UNIT II OPEN LOOP SYSTEMS

Laplace transformation, application to solve ODEs. Open-loop systems, first order systems and their transient response for standard input functions, first order systems in series, linearization and its application in process control, second order systems and their dynamics; transportation lag.

UNIT III CLOSED LOOP SYSTEMS

Closed loop control systems, development of block diagram for feed-back control systems servo and regulatory problems, transfer function for controllers and final control element

UNIT IV FREQUENCY RESPONSE

Introduction to frequency response of closed-loop systems, control system design by frequency response techniques, Bode diagram, stability criterion, tuning of controller settings.

UNIT V ADVANCED PROCESS CONTROL AND BIOSENSORS

Introduction to advanced control systems, cascade control, feed forward control On-line analysis of process parameters; Introduction to biosensors; Transduction principles used in biosensors; Characteristics of biosensors; Biosensors based on amperometric, potentiometric, thermistor FET, fiber optics and bioluminescence; Microbial biosensors; Fundamentals of digital process control; Use of computer in control and optimization of microbiological processes. Artificial neural networking and use in prediction of bioprocess and control

TOTAL 45 PERIODS

TEXT BOOKS:

1. Stephanopoulos, G., “Chemical Process Control“, Prentice Hall of India, 2003.
2. Coughnowr, D., “ Process Systems Analysis and Control “,. 3rd ed., McGraw Hill, 2008.
3.Sensors in Bioprocess Control (Biotechnology and Bioprocessing Series) by John Twork , 2020

REFERENCES:

1. Process Control Instrumentation Technology (8th Edition) by Curtis Johnson ,2008
2. Marlin, T. E., “ Process Control “, IInd Edn, McGraw Hill, New York, 2000.
3. Smith, C. A. and Corripio, A. B., “Principles and Practice of Automatic Process Control”,IInd Edn., John Wiley, New York, 1997.