BT3552 Immunology Syllabus:

BT3552 Immunology Syllabus – Anna University Regulation 2021

OBJECTIVES:

 To discuss the structure, functions and integration of immune system.
 To explain the immune response and protective mechanism against various pathogens.

UNIT I INTRODUCTION TO IMMUNE SYSTEM

Organisation and classification of immune system – immune cells and organs; innate and acquired immunity; Toll receptors and responses, classification of antigens – chemical and molecular nature; haptens, adjuvants; cytokines; complement pathway, antigen presenting cells; major histocompatibility complex

UNIT II HUMORAL AND CELLULAR IMMUNITY

Development, maturation, activation, regulation, differentiation and classification of T-cells and Bcells, antigen processing and presentation, theory of clonal selection, TCR; antibodies: structure and functions; antibodies: genes and generation of diversity; antigen-antibody reactions

UNIT III IMMUNITY AGAINST PATHOGENS AND TUMORS

Inflammation; protective immune responses to virus, bacteria, fungi and parasites; tumor antigens, tumor immune response, tumor diagnosis, tumor immunotherapy

UNIT IV IMMUNE TOLERANCE AND HYPERSENSITIVITY

Immune tolerance, Immuno deficiencies; Transplantation – genetics of transplantation; laws of transplantation; Allergy and hypersensitivity – Types of hypersensitivity, Autoimmunity, Auto immune disorders and diagnosis

UNIT V APPLIED IMMUNOLOGY

Monoclonal antibodies, engineering of antibodies; T- Cell cloning – Classification of Vaccines, methods of vaccine development, immunodiagnostic methods (Immuno diffusion ELISA, FACS), immune modulatory drugs

TOTAL: 45 PERIODS

OUTCOMES:

Upon completion of the course, students will be able to
 Understand the structure, functions and integration of immune system.
 Understand the antigen-antibody interactions that offers defence mechanism.
 Gain knowledge in importance of learning immunoregulation in Immunity development
 Understand the importance of various techniques of therapeutically significant monoclonal and engineered antibodies production
 Aware of the concepts and mechanism behind tumour development, allergy and hypersensitivity reactions.
 Gain knowledge in Immunotherapeutic development for Clinical Applications

TEXT BOOKS:

1. Peter J Delves, Seamus J Martin, Dennis R Burtn and Ivan M Roitt., Roitts Essential Immunology, 13th Edition, Wiley –Blackwell, 2016.
2. Judith a Owen, Jenni Punt and Sharon A Stranford, Kuby Immunology, Macmillan Internation, 7th Edition, 2012
3. Ashim K. Chakravarthy, Immunology, Tata McGraw-Hill, 2006.

REFERENCES:

1. Coico, Richard “Immunology: A Short Course” VIth Edition. John Wiley, 2008.
2. Khan, Fahim Halim “Elements of Immunology” Pearson Education, 2009.
3. Robert R Rich, Thomas A Fleisher, William T Shearer, Harry Schroeder, Anthony J Frew, and Cornelia M Weyand, Clinical Immunology – Principles and Practive, Elsevier, 4th Edition, 2013.
4. Maurice R, G O`Gorman, and Albert D Donnnenberg, Handbook of human Immunology, Second edition, CRC Press, 2008
5. Gerd – Rudiger Burmester, , Antonio Pezzutto and Jurgen Wirth, Colour Atlas of Immunology, Thieme Medical Publishers, 1st Edition, 2003.