CES333 Sustainable Biomaterials Syllabus:
CES333 Sustainable Biomaterials Syllabus – Anna University Regulation 2021
COURSE OBJECTIVES
To Impart knowledge of biomaterials and their properties
To learn about Fundamentals aspects of Biopolymers and their applications
To learn about bioceramics and biopolymers
To introduce the students about metals as biomaterials and their usage as implants
To make the students understand the significance of bionanomaterials and its applications.
UNIT I INTRODUCTION TO BIOMATERIALS
Introduction: Definition of biomaterials, requirements & classification of biomaterials- Types of Biomaterials- Degradable and resorbable biomaterials- engineered natural materials Biocompatibility-Hydrogels-pyrolitic carbon for long term medical implants-textured and porous materials-Bonding types- crystal structure-imperfection in crystalline structure-surface properties and adhesion of materials –strength of biological tissues-performance of implants-tissue response to implants- Impact and Future of Biomaterials
UNIT II BIO POLYMERS
Molecular structure of polymers -Molecular weight – Types of polymerization techniques–Types of polymerization reactions- Physical states of polymers- Common polymeric biomaterials – Polyethylene -Polymethylmethacrylate (PMMA-Polylactic acid (PLA) and polyglycolic acid (PGA) – Polycaprolactone (PCL) – Other biodegradable polymers –Polyurethan- reactions polymers for medical purposes – Collagens- Elastin- Cellulose and derivatives-Synthetic polymeric membranes and their biological applications
UNIT III BIO CERAMICS AND BIOCOMPOSITES
General properties- Bio ceramics -Silicate glass – Alumina (Al2O3) -Zirconia (ZrO2)-Carbon- Calcium phosphates (CaP)- Resorbable Ceramics- surface reactive ceramics- Biomedical Composites Polymer Matrix Compsite(PMC)-Ceramic Matrix Composite(CMC)-Metal Matrix Composite (MMC)– glass ceramics – Orthopedic implants-Tissue engineering scaffolds
UNIT IV METALS AS BIOMATERIALS
Biomedical metals-types and properties-stainless steel-Cobalt chromium alloys-Titanium alloysTantalum-Nickel titanium alloy (Nitinol)- magnesium-based biodegradable alloys-surface properties of metal implants for osteointegration-medical application-corrosion of metallic implants – biological tolerance of implant metals
UNIT V NANOBIOMATERIALS
Meatllicnanobiomaterials–Nanopolymers-Nanoceramics- Nanocomposites -Carbon based nanobiomaterials – transport of nanoparticles- release rate-positive and negative effect of nanosizenanofibres-Nano and micro features and their importance in implant performance-Nanosurface and coats-Applications nanoantibiotics-Nanomedicines- Biochips – Biomimetics- BioNEMs -BiosensorBioimaging/Molecular Imaging- challenges and future perspective.
TOTAL : 45 PERIODS
COURSE OUTCOMES
CO1 Students will gain familiarity with Biomaterials and they will understand their importance.
CO2 Students will get an overview of different biopolymers and their properties
CO3 Students gain knowledge on some of the important Bioceramics and Biocomposite materials
CO4 Students gain knowledge on metals as biomaterials
CO5 Student gains knowledge on the importance of nanobiomaterials in biomedical applications.
REFERENCES
1. C. Mauli Agrawal, Joo L. Ong, Mark R. Appleford, Gopinath Mani “Introduction to Biomaterials Basic Theory with Engineering Applications” Cambridge University Press, 2014.
2. Donglu shi “Introduction to Biomaterials” Tsinghua University press, 2006.
3. Joon Park, R.S.Lakes “Biomaterials An Introduction” third edition, Springer 2007.
4. M.Jaffe,W.Hammond, P.Tolias and T.Arinzeh “Characterization of Biomaterials” Wood head publishing, 2013.
5. Buddy D.Ratner and Allan S.Hoffman Biomaterials Science “An Introduction to Material in Medicine” Third Edition, 2013.
6. VasifHasirci, NesrinHasirci “Fundamentals of Biomaterials” Springer, 2018
7. Leopoido Javier Rios Gonzalez. “Handbook of Research on Bioenergy and Biomaterials: Consolidated and green process” Apple academic press, 2021.
8. Devarajan Thangadurai, Jeyabalan Sangeetha, Ram Prasad “Functional Bionanomaterials” springer, 2020.
9. Sujata.V.Bhat Biomaterials; Narosa Publishing house, 2002.