CBM339 Biomedical Optics and Biophotonics Syllabus:
CBM339 Biomedical Optics and Biophotonics Syllabus – Anna University Regulation 2021
COURSE OBJECTIVES
● To acquire knowledge about the physical properties of light and optical properties of tissues.
● Learn the design and working principle of various optical components.
● Understand the principles and applications of optical biosensors.
● Understand the engineering and practical applications of optics related to diagnostic and surgical applications.
● Understand the phenomenon of laser tissue interaction and practical applications of optics related to therapeutic applications.
UNIT I OPTICAL PROPERTIES
Basic principles of light – Reflection – Refraction – Absorption – Polarization – Interference – Coherence, Basic laws of light – Beer Lambert law – Snell’s law, Optical properties of tissues – Absorption – Scattering – Anisotropy.
UNIT II OPTICAL INSTRUMENTATION
Working principle of light sources – Lasers – LEDs, Working principle of optical detectors – Photodiode – Spectrometer – CMOS and CCD cameras – Lens – Optical filters – Optical fibers.
UNIT III OPTICAL BIOSENSORS
Principles of Optical biosensing – Immobilization of bio-recognition elements, Types of optical biosensor – Fiber optic – Planar waveguide – Evanescent – Interferometric – Surface plasmon resonance ˗ Advantages and disadvantages – Applications.
UNIT IV APPLICATIONS OF LASERS
Diagnostic – Optical coherence tomography, Fluorescence, Raman, Photoacoustic tomography, Laser induced breakdown spectroscopy (LIBS), Hyperspectral imaging. Surgical – Lasers in dentistry, Dermatology, Ophthalmology.
UNIT V LASER TISSUE INTERACTION
Laser tissue interactions via photochemical, Photothermal, Photomechanical techniques, Photodynamic therapy (PDT) – Oncological and non-oncological applications, Low level laser therapy (LLLT) – Biostimulation applications.
30 PERIODS
Lab course/Mini projects/Hospital visit – Presentations (30 hours)
Students need to visit Hospitals/Research Institutes/Industry and understand the working and applications of various Optical Techniques in the Biomedical field.
Lab course/Mini projects on interferometry techniques (Young’s double slit, Michelson and Mach-zehnder interferometry).
Lab course/Mini projects on various spectroscopic techniques (absorption/transmission, scattering and emission spectroscopy).
Lab course/Mini projects on optical simulations and image processing – MATLAB, COMSOL, optical softwares.
Mini projects on Laser based Biomedical Applications
Hospital visit to understand the working of Optical Coherence Tomography technique Hospital visit to understand the clinical applications of Lasers used in ophthalmology, dermatology, dentistry, etc.,
30 PERIODS
TOTAL: 60 PERIODS
COURSE OUTCOMES
On successful completion of this course, the student will be able to
CO1: Explain the various physical properties of light and optical properties of tissues.
CO2: Consolidate the working principles of optical components.
CO3: Discuss the various applications of biosensors in medicine.
CO4: Summarize the diagnostic and surgical applications of lasers in medicine.
CO5: Explain the laser tissue interaction and various therapeutic applications of lasers.
TEXT BOOKS
1. Tuan Vo Dinh, “Biomedical Photonics –Handbook, CRC Press, Bocaraton, 2014.
2. Jurgen Popp, Valery V. Tuchin, Arthur Chiou and Stefen Heinemann, Handbook of Biophotonics, Vol 2: Photonics for Healthcare, John Wiley and Sons, 1st Edition, 2011.
REFERENCES
1. Markolf H. Niemz, “Laser-Tissue Interaction Fundamentals and Applications” Springer, 2007.
2. Splinter R and Hooper B. A., “An Introduction to Biomedical Optics”, Taylor and Francis, 2006.
3. Mark E. Brezinski, “Optical Coherence Tomography: Principles and Applications”, Academic Press, 2006.
4. Paras N. Prasad, “Introduction to Biophotonics”, A. John Wiley and sons, Inc. Publications, 2003.