CBM337 Biomaterials Syllabus:

CBM337 Biomaterials Syllabus – Anna University Regulation 2021

COURSE OBJECTIVES:

The student should be made to:
 Learn characteristics and classification of Biomaterials
 Understand different metals, ceramics and its nanomaterial’s characteristics as biomaterials
 Learn polymeric materials and its combinations that could be used as a tissue replacement implants
 Get familiarized with the concepts of Nano Science and Technology
 Understand the concept of biocompatibility and the methods for biomaterials testing

UNIT I INTRODUCTION TO BIO-MATERIALS

Definition and classification of bio-materials, mechanical properties, visco elasticity, biomaterial performance, body response to implants, wound healing, blood compatibility, Nano scale phenomena.

UNIT II METALLIC AND CERAMIC MATERIALS

Metallic implants – Stainless steels, co-based alloys, Ti-based alloys, shape memory alloy, nanostructured metallic implants, degradation and corrosion, ceramic implant – bio inert, biodegradable or bioresorbable, bioactive ceramics, nanostructured bio ceramics.

UNIT III POLYMERIC IMPLANT MATERIALS

Polymerization, factors influencing the properties of polymers, polymers as biomaterials, biodegradable polymers, Bio polymers: Collagen, Elastin and chitin. Medical Textiles, Materials for ophthalmology: contact lens, intraocular lens. Membranes for plasma separation and Blood oxygenation, electro spinning: a new approach.

UNIT IV TISSUE REPLACEMENT IMPLANTS

Small intestinal sub mucosa and other decullarized matrix biomaterials for tissue repair: Extra cellular Matrix. Softtissue replacements, sutures, surgical tapes, adhesive, Percutaneous and skin implants, maxillofacial augmentation, Vascular grafts, hard tissue replacement Implants, joint replacements, tissue scaffolding and engineering using Nano biomaterials.

UNIT V TESTING OF BIOMATERIALS

Biocompatibility, blood compatibility and tissue compatibility tests, Toxicity tests, sensitization, carcinogenicity, mutagenicity and special tests, Invitro and Invivo testing; Sterilisation of implants and devices: ETO, gamma radiation, autoclaving. Effects of sterilization.

COURSE OUTCOMES:

On successful completion of this course, the student will be able to
CO1: Analyze different types of Biomaterials and its classification and apply the concept of nanotechnology towards biomaterials use.
CO2: Identify significant gap required to overcome challenges and further development in metallic and ceramic materials
CO3: Identify significant gap required to overcome challenges and further development in polymeric materials
CO4: Create combinations of materials that could be used as a tissue replacement implant.
CO5: Understand the testing standards applied for biomaterials.

TOTAL:45 PERIODS

TEXTBOOKS

1. Sujata V. Bhatt, “Biomaterials”, Second Edition, Narosa Publishing House, 2005.
2. JoonB.Park Joseph D. Bronzino, “Biomaterials – Principles and Applications”, CRC press, 2003

REFERENCES

1. Sreeram Ramakrishna, MuruganRamalingam, T. S. Sampath Kumar, and Winston O. Soboyejo, “Biomaterials: A Nano Approach”, CRC Press, 2010.
2. Monika Saini, Yashpal Singh, Pooja Arora, Vipin Arora, and KratiJain. “Implant biomaterials: A comprehensive review”, World Journal of Clinical Cases, 2015.
3. Biomaterials- Basic Theory with Engineering Applications C.Mauli Agarwal, Joo L.Ong, Mark R. Appleford, Gopinath Mani. Cambrige University Press, New York- 2016.