CH3012 Bioprocess Technology Syllabus:
CH3012 Bioprocess Technology Syllabus – Anna University Regulation 2021
COURSE OBJECTIVES:
To understand the fundamentals of bioprocesses
To understand the production process of biomolecules
To have a strong foundation in bioreactors.
UNIT I INTRODUCTION TO BIOPROCESS
Biologists and Engineers, comparison of chemical and biochemical processing overview of biological basics, About cells and its growth, the stoichiometry of microbial growth and product Bioprocesses: Regulatory Constraints
UNIT II MEDIA FORMULATION AND DEVELOPMENT
Media formulation, Media Sterilization: Methods of heat sterilization of media, thermal death kinetics, design criteria, batch and continuous sterilization. Air Sterilization: Methods of air sterilization, mechanism of air sterilization, solid and liquid handling. Industrially fermented broth
UNIT III UNDERSTANDING BIOREACTORS
Purpose and importance of bioreactors, Classification of bioreactors, bioreactors for animal cells, bioreactors for plant cells, bioreactors for immobilized cells, operations of bioreactors, stirred tank reactor, plug flow reactor (PFR), fluidized bed reactor, bubble column, airlift reactor, Agitation, and Aeration: Mechanical agitation, power consumption in agitation, bubble aeration, bioreactors for waste management
UNIT IV TRANSPORT PROCESSES
Aspects of rheology, Fluid flow in packed-bed and Fluidized bed columns, Gas-liquid mass transfer in cellular systems Diffusivity and mechanism of mass transfer – derivation of the equations of mass transport by diffusion-stationary and unsteady mass transport by diffusion, mass transfer coefficient, macroscopic balances for mass transport. Mechanisms and applications of heat transfer-mode of heat transfer-conduction, convection and radiation, Application of Heat and Mass transfer in biochemical processes.
UNIT V BIOETHICS AND BIOSAFETY
Introduction to Bioethics. Social and ethical issues, the process of biotechnology involved in generating new forms of life for informed decision making, Definition of Biosafety. Biosafety for human health and environment. Social and ethical issues. Use of genetically modified organisms and their release into the environment.
TOTAL: 45 PERIODS
OUTCOMES:
On completion of the course, the students will be able to
CO1- understand the fundamental knowledge on bioprocess technology
CO2- learn the the production process of biomolecules
CO3- gather knowledge on the operations of bioreactors and their purposes
CO4- understand the transportation processes in reactors and their behaviors
CO5- knowledge on the biosafety and information on bioethics.
TEXT BOOKS:
1. Bailey, J. E., and D. F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York, McGraw-Hill, 1986.
2. H. W. Blanch and D. S. Clark, Biochemical Engineering, Marcel, Dekker Inc., 1996.
3. Pauline M. Doran. Bioprocess Engineering Principles. 2nd ed. Elsevier Science & Technology Books. 1995
REFERENCES
1. Transport Phenomena, by Bird R.B., Steward W.E., and Lightfoot E.N., John Wiley & sons, Inc., New York, 2002
2. C J Geankoplis, Transport Processes and Separation Processes Principles, 4th Edition, New Jersey, PHI Publishers, 2010