CH3016 Bioreactor Design Syllabus:
CH3016 Bioreactor Design Syllabus – Anna University Regulation 2021
COURSE OBJECTIVES:
To understand the fundamentals of bioreactor design
To design single and multiple bioreactors
To design a bioprocess system.
UNIT I BIOREACTOR DESIGN & MEDIA REQUIREMENTS
Microbial growth and product formation kinetics, Bioreactor Selection, Reactor operational mode and selection.
UNIT II DESIGN EQUATIONS FOR BIOREACTORS
Basic Design Equations/ Mole Balances: Batch, Fed-Batch and Repetitive Batch Reactors, Continuous: Stirred tank and tubular flow reactors, Microbial death kinetics, Design criterion for sterilization, Batch and continuous sterilization of medium, Multiple reactions-series, parallel and mixed-mode, Air sterilization
Unit III BIOREACTOR REQUIREMENTS
Process-General requirements; Basic design and construction of bioreactors and their ancillaries; Material of construction, Vessel geometry, Bearing Assemblies, Motor drives, Aseptic seals; Flow measuring devices, Valves, Agitator and Sparger Design, Sensors, Non-isothermal homogeneous reactor systems. Adiabatic reactors, batch and continuous reactors, optimum temperature progression
UNIT IV DESIGN OF BIOREACTORS
Process and mechanical design of Bioreactors, volume, sparger, agitator-type, size and motor power, heat transfer calculations for coil and jacket, sterilization system, scale-up, scale down, bioinstrumentation and control.
UNIT V NOVEL BIOREACTORS DESIGN
Design of Immobilized enzyme packed bed Reactor. Fluidized bed reactors, Slurry Reactors, Airlift & Loop reactors, Packed bed and Hollow fiber membrane bioreactors, Bioreactors for waste treatment processes; SSF bioreactors. bioreactor design considerations for plant and animal cell cultures.
TOTAL : 45 PERIODS
COURSE OUTCOMES:
On completion of the course, the students will be able to
CO1: Compare kinetics and reaction rates for various bioreactor designs, based on operational mode and type of substrate.
CO2: Differentiate and estimate productivity in commercial bioreactors- packed bed, fed batch reactors
CO3:Helps to understand various requirements such as material of construction, valves, agitator, sensors etc
CO4:Understanding the mechanical design and heat transfer calculations for various type of bioreactor
CO5: Analyze immobilization techniques in reactors and use it for various applications
TEXT BOOKS:
1. Bioprocess Engineering -Kinetics, Mass Transport, Reactors and Gene Expression Wolf R. Vieth A Wiley-Interscience Publication 1994
2. Chemical Kinetic Methods: Principles of relaxation techniques Kalidas C New Age International 1996
3. Chemical Reactor Analysis and Design Forment G F and Bischoff K B John Wiley 1990
REFERENCE:
Bioprocess Engineering -Kinetics, Biosystems, sustainability and reactor Design, Shijie Liu, Elsevier Publication 2013.