CBT331 Bioprocess Modelling and Simulation Syllabus:
CBT331 Bioprocess Modelling and Simulation Syllabus – Anna University Regulation 2021
COURSE OBJECTIVES
The student should be made to,
To understand the mathematical models in Biochemical Engineering systems.
To learn about different aspects of modelling in Bioprocess system.
To learn various techniques to solve and simulate various bioprocess models.
UNIT I BASIC MODELLING PRINCIPLES
Introduction, definition of Modelling and simulation, different types of models, application of mathematical modelling. Fundamental laws: continuity equation, energy equation, equation of
motion, transport equation, equation of state, Phase and chemical equilibrium, chemical kinetics with examples.
UNIT II MATHEMATICAL MODELS FOR BIOREACTOR SYSTEMS
Batch reactor, CSTR isothermal with cooling/heating jacket or coil, Fed Batch reactor.
UNIT III MODELLING APPROACHES FOR BIOLOGICAL SYSTEMS
Growth kinetic Models – structured and unstructured systems; Compartment models; Cybernetic models; Genetically structured models, Single cell models, Morphologically structured models. Thermal death kinetics models, Stochastic Model for thermal sterilization of medium.
UNIT IV MODELLING APPROACHES FOR BIOLOGICAL PROCESSESS
Modelling for activated sludge process, Model for anaerobic digestion, Model for lactic acid fermentation, antibiotic production, Ethanol fermentation.
UNIT V SIMULATION OF BIOPROCESSES
Software packages for simulation of bioprocesses – MATLAB-SIMULINK, Creating bioprocess models in MATLAB and Simulink environment. Linear and non-linear estimation of the kinetic parameters for types and models.
TOTAL 45 PERIODS
COURSE OUTCOMES
Upon completion of this course the student will be able to
To understand the basic modelling principles in Biochemical Engineering systems.
Apply the knowledge of modeling concepts for bioreactor design.
To formulate model for biological System.
To utilize modelling approaches for various bioprocess estimation.
To build kinetic simulation models of the cell growth and product formation.
To connect different models together to build a bioprocess model.
TEXT BOOKS:
1. Luyben W.L., “Process Modeling, Simulation and control for Chemical Engineers”, McGraw Hill, 2nd Edition, 2013.
2. Bailey J.A and Ollis D.F., “Biochemical Engineering Fundamentals”, McGraw Hill (New York), 2nd Edition, 2010.
3. T.K.Ghose., “Bioprocess Computations in Biotechnology-Vol.I”, Ellis Horwood Ltd. 1989
REFERENCES:
1. Perry R H ,“Perry’s Chemical Engineers’ Handbook”, McGraw-Hill, 8th Edition, 2008